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Markab plague
Did we ever find out whether the Draffa that killed the Markab was related to the Shadows? I mean, a virus that's 100% contageous, 100% deadly, is almost impossible to analyze (Franklin only found a workaround, remember, he never found the agent itself) showed up some time in the past, then showed up again immediately before the final Shadow War... sounds like a rather odd coincidence, no?
Comments
In fact, the virus that wiped out the Markab is similar in mechanism to existing viruses today.
The shadow virus is something else, but you have to watch the last episode of crusade to find out just how weird it is...